If you’re battling bloating, abdominal pain, headaches, or any other symptoms related to consuming gluten, you may want to consider eliminating cross-reactive foods. When this happens, your immune system can view the two as the same. In other words, if you add cheese to your gluten-free bread, but you still experience bloating, gas, headaches, and other symptoms of gluten intolerance, the proteins in cheese could be to blame. “Just in the same way that antibodies can mistake the body’s own tissues for the gluten-related foreign molecules, if there are other foods that have very similar molecular structures to them as well, the antibodies that have already been made to recognize and attack the gluten-related molecules can also recognize and attack these other food molecules too,” says Stephanie Berg, N.D. When this happens, Berg says the immune system can go into overdrive, resulting in inflammation-induced pain. Gluten is just one protein found in wheat, rye, and barley, but there are other proteins that share a very similar molecular structure to gluten. “As such, in a person whose immune system is activated to react to the gluten protein, the immune system may also attack and react to these other proteins which mimic gluten,” explains cardiologist Steven Gundry M.D. In a paper he presented at the American Heart Association Lifestyle and Epidemiology Annual Conference and published in the journal Circulation, he reported that 70% of gluten-sensitive patients react to several proteins in corn. Rice, he found, also has a protein that mimics gluten. Lyla Blake-Gumbs, M.D., a board-certified family and functional medicine physician at SteadyMD, says food proteins with amino acid (protein subunits) similar enough to be “confused” with the proteins in gluten can cause this type of cross-reactivity. According to a 2013 study published in Food and Nutrition Sciences, close to 30 percent of patients with gluten sensitivity have a poor response and continue to experience symptoms on a gluten-free diet. The lack of improvement in symptoms after following a gluten-free diet, they say, may be associated with dietary non-adherence or cross-reactive epitopes triggering a state of heightened immunological reactivity in gluten-sensitive individuals. In other words, other foods they’re eating can cause a similar gluten-induced reaction. Berg agrees: She says in gluten-sensitive individuals, the foods that potentially cross-react with gluten include dairy products such as milk and cheese (and all their smaller protein molecules, such as various forms of casein, casomorphin, butyrophilin, and whey protein), corn, yeast, oats, rice, millet, and instant coffee (yes, really!). “The same antibodies that attack the gluten-related protein gliadin can also attack these foods,” she says. That said, Berg does point out that depending on the part of the gluten-related protein you are sensitive to (glutenin or gliadin) and it’s specific molecular structure, those antibodies may or may not mistake certain other foods. “So, while not all people with gluten-related sensitivity will necessarily be sensitive to all of these foods, there is a risk that they could stimulate the immune system,” she adds. The only way to circumvent these reactions, according to Blake-Gumbs, is to do a complete elimination diet that removes many of these foods for a period of no less than three to four weeks. “This allows the body to rid itself of these preformed antibodies,” she says. Essentially, you may need to follow a gluten-free diet that also eliminates cross-reactive foods such as corn, rice, oats, millet, dairy, and food that contains yeast. After a minimum of four weeks, you can begin the process of reintroducing these cross-reactive foods into your diet to see if any of the preexisting symptoms are triggered. If you can add dairy back and not experience bloating, abdominal pain, or any other symptoms of gluten sensitivity, then you may be able to add dairy products like cheese and yogurt to the list of foods you can eat. However, if you begin to experience those same symptoms within 24 to 48 hours of eating one of these foods, you may want to consider eliminating it from your diet permanently.
